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Pain · A protective percept built from nociception, context and prediction.

Reviewed 2026-08·Sources & research·Media credits

Santiago Ramón y Cajal
PainOriginal photo is anonymous although published by Clark University in 1899. Restoration by Garrondo · Public domain · Wikimedia Commons

People who shaped how we talk about Pain.

Eight voices span anatomy, clinic, computation and culture.

People

01 Santiago Ramón y Cajal

Santiago Ramón y Cajal

1852–1934 · Spain

Neuron doctrine

Santiago Ramón y Cajal shaped discourse on protective sensory gain relevant to Pain.

02 Rita Levi-Montalcini

Rita Levi-Montalcini

1909–2012 · Italy

Nerve growth factor

Rita Levi-Montalcini shaped discourse on protective sensory gain relevant to Pain.

03

John O'Keefe

b. 1939 · US/UK

Place cells

John O'Keefe shaped discourse on protective sensory gain relevant to Pain.

04 Eric Kandel

Eric Kandel

b. 1929 · Austria/US

Cellular learning

Eric Kandel shaped discourse on protective sensory gain relevant to Pain.

05 Wilder Penfield

Wilder Penfield

1891–1976 · Canada

Cortical maps

Wilder Penfield shaped discourse on protective sensory gain relevant to Pain.

06 David Hubel

David Hubel

1926–2013 · Canada/US

Visual columns

David Hubel shaped discourse on protective sensory gain relevant to Pain.

07

May-Britt Moser

b. 1963 · Norway

Grid cells

May-Britt Moser shaped discourse on protective sensory gain relevant to Pain.

08

Edvard Moser

b. 1962 · Norway

Grid cells

Edvard Moser shaped discourse on protective sensory gain relevant to Pain.

Portraits resolve via Wikimedia when Commons licences allow.

Sources & research

  1. Pain mechanisms: a new theoryMelzack R; Wall PD · 1965 · ScienceDOIPubMed
  2. Neurobiology of painBasbaum AI; et al. · 2009 · CellDOIPubMed
  3. Chronic pain as a disease of the brainApkarian AV; Baliki MN; Geha PY · 2009 · NeuroscientistDOI

Media credits

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