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IHow influenza infects and changes

Influenza ? A winter respiratory virus of drift and rare shift — surveillance and vaccines, not a cartoon villain.

Inhaled particles reach airway cells. Replication is fast; fever and cough follow an innate alarm.

Each copy round adds mutants. Most fail. A few drift the surface enough to matter next winter.

Parts

HA entry

Hemagglutinin helps the particle attach to airway sugars.

NA exit

Neuraminidase helps new particles leave the cell surface.

Nucleus step

Unusual for an RNA virus, influenza replication uses the host nucleus.

Airway damage

Killed cells and inflammation make secondary bacterial pneumonia more likely in some people.

Antibody target

HA head changes fastest; stem is more conserved and a research aim for broader shots.

Animal mixers

Pigs and birds can host several A viruses; that ecology is watched, not recreated at home.

Life cycle

1Inhale

Droplets or aerosols reach a new airway.

2Replicate

Airway cells make huge numbers of particles for a few days.

3Shed and feel ill

Cough and contact move virus while fever and aches peak.

4Recover or complicate

Most people recover. A minority develop pneumonia or worsening of chronic disease.

No engineering steps are described.

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