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AOpen questions in resistance

Antibiotic resistance ? A shared drug budget under selection in hospitals, farms and wastewater — stewardship, not a lab manual.

Science can find new targets; economics must pay for them. Diagnostics must be fast enough to withhold a drug.

Phage, antibodies and vaccines share the load in research talk. None is a household recipe here.

Open questions

Who pays for new classes?

Markets under-reward drugs meant to be used sparingly. Pull incentives are a live policy debate.

Can rapid tests cut empiric use?

If a clinic can tell virus from bacterium in minutes, fewer unneeded courses start.

How do we watch farms and rivers?

Genomic surveillance of wastewater and livestock is expanding; sharing data is political.

Will phage replace pills?

Phage therapy is researched for some resistant infections. It is not a home kit and not a universal swap.

What does success look like?

Falling unnecessary use, stable last-line drugs, and fewer outbreaks of resistant clones in hospitals.

The frontier is governance of a shared chemical commons.

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