Personalised DBS
Can closed-loop stimulation match symptom dynamics?
Open questions include how to personalise DBS, how AI prostheses close the loop, and how to measure real-world skill — not just lab reaches.
Brain–computer interfaces and adaptive stimulation are active frontiers — hype included.
Open questions
Synergy primitives
How many true building blocks does the nervous system use?
Transfer of skill
When do lab gains generalise to cluttered life?
Aging vs disease
Which motor changes are pathology, which are adaptation?
Embodied AI control
Can robots borrow human forward-model principles usefully?
Technology
Adaptive DBS platforms
Sense biomarkers and titrate stimulation.
High-DOF neural prostheses
Decode intention with sensory feedback loops.
Markerless motion AI
Bring clinic-grade kinematics to everyday video.
Soft exosuits
Augment gait without rigid frames.
VR perturbation rehab
Controlled error exposure for adaptation.
Ethics
Enhancement vs therapy
Who accesses motor BCIs beyond clinical need?
Agency after DBS
Patients must retain narrative ownership of action.
Data from bodies
Kinematic surveillance can become workplace control.
Prefer mechanisms and base rates over “neuro-gaming” marketing.
Sources & research
- Error correction, sensory prediction, and adaptation in motor controlSynthesis of prediction and adaptation in motor control.DOI
- Ethological Action Maps: A Paradigm Shift for the Motor CortexAction-map view of motor cortex organisation.DOI
- The basal ganglia: focused selection and inhibition of competing motor programsCanonical basal-ganglia selection model.DOI
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