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BBacteriophages: how they work

Bacteriophages ? Viruses that infect bacteria — Earth's most abundant biological entities, and a concept-level idea in medicine.

A tailed phage binds a receptor, contracts, and injects nucleic acid. Minutes later in a rich broth, hundreds of new particles may assemble. In the ocean the same logic runs more slowly.

Lysogeny is a truce: the phage genome rides along as the bacterium divides. UV or starvation can flip the switch to lysis. Description, not a recipe.

Parts

Head (capsid)

Usually an icosahedron packed with DNA. T4's head is a textbook icon about 110 nm long.

Tail

A tube that can contract in myoviruses. Not every phage has a tail — filamentous phages are threads.

Tail fibres

The matching keys. Change the fibre and the host range can change — a research fact, not instructions.

Genome

Typically DNA, from a few kilobases to half a megabase in jumbo phages. RNA phages exist too (MS2, 1961).

Baseplate

A landing gear that signals 'we have docked' before DNA moves.

No 70S factory

Protein synthesis is entirely the bacterium's. Phages are instructions plus a syringe.

Life cycle

1Adsorb

Fibres find a receptor — LPS, a porin, a pilus. No match, no infection.

2Inject

Nucleic acid enters the cytoplasm. The empty capsid stays outside — Hershey–Chase used that fact.

3Take over or integrate

Lytic programmes copy phage DNA. Temperate programmes may insert as prophage.

4Burst or wait

Lysis releases a burst of tens to hundreds of particles. Lysogeny waits for a later cue.

When headlines say a phage 'evolved overnight', they mean huge numbers and tight host matching, not a cartoon villain.

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