Joseph LeDoux
b. 1949 · USAFear circuits
Mapped amygdala pathways for defensive responding.
Anxiety · Threat circuitry, worry loops and avoidance — how brains over-predict danger and how care can recalibrate risk.
Reviewed 2026-08·Sources & research·Methodology·Media credits
Eight voices who shaped threat learning, clinical taxonomy and evidence-based anxiety care.
Portraits resolve via Wikimedia when licences allow.
Fear circuits
Mapped amygdala pathways for defensive responding.
Inhibitory learning
Modern exposure theory emphasising new safety learning.
Cognitive model
Cognitive therapy foundations for anxiety and depression.
Unified protocols
Transdiagnostic approaches to emotional disorders.
Fear-potentiated startle
Rigorous behavioural neuroscience of fear learning.
Trait anxiety
Early dimensional views of neuroticism and conditioning.
Exposure therapy
Influential exposure frameworks for anxiety and PTSD.
Epidemiology
Syntheses of anxiety epidemiology and treatment guidelines.
Read primary papers; this page is not care.
Progressive dementia driven by protein pathology and network failure.
Research 74 🤲Dopamine circuit loss, movement symptoms and non-motor features.
Research 54 ⚡Sudden vascular injury — time, territory and the race to recover.
Research 64 ⚡Hyperexcitable networks, seizures and modern treatment options.
Research 95 🌧️Mood circuits, stress biology and evidence-based interventions.
Research 66 🌀Perception, belief and cognition when predictive models go awry.
Research 93 💢Sensory gain, aura and the brain’s recurrent pain networks.
Research 74 📱Attention control, impulsivity and developmental self-regulation.
Research 51 🧩Neurodevelopmental diversity in social communication and sensory processing.
Research 89 🧬Immune attack on myelin — disconnection across white-matter highways.
Research 80 🩹Mechanical insult, diffuse injury and the long arc of recovery.
Research 87 🔁Compulsive seeking when reward prediction and control circuits tip.
Research 69 ⚖️Mania, depression and the networks between — mood-state biology, sleep disruption and evidence-based stabilising care.
Research 84 🛡️Trauma memory, hyperarousal and avoidance — how threat learning overgeneralises and how evidence-based care supports recovery.
Research 87