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Anxiety · Threat circuitry, worry loops and avoidance — how brains over-predict danger and how care can recalibrate risk.

Reviewed 2026-08·Sources & research·Methodology·Media credits

Anxiety
AnxietyEdvard Munch · Public domain · Wikimedia Commons

Clinical care distinguishes everyday worry from disorders that impair function. Assessment looks at duration, avoidance, panic, substances and medical mimics.

Educational neuroscience context only — not medical advice, diagnosis or a substitute for emergency or clinical care. If you are in crisis, seek local emergency services or a licensed clinician.

Conditions

Generalised anxiety disorder

Persistent free-floating worry and tension.

Panic disorder

Recurrent unexpected panic and fear of recurrence.

Social anxiety disorder

Fear of negative evaluation in social settings.

Specific phobia

Intense fear of particular cues with avoidance.

Agoraphobia

Fear of situations where escape/help feels hard.

Medical / substance mimics

Thyroid, caffeine, stimulants and others can mimic anxiety.

Signs

Excessive worry

Hard to control, disproportionate to evidence.

Avoidance shrinking life

Roles, travel or relationships drop out.

Panic surges

Sudden peaks of fear with bodily symptoms.

Sleep / muscle tension

Hyperarousal that exhausts recovery.

Safety behaviours

Ritual checks that maintain the fear cycle.

Care themes

CBT with exposure

First-line for many anxiety presentations when available.

SSRI / SNRI when indicated

Medication decisions belong with licensed clinicians.

Sleep & stimulant hygiene

Reduce amplifiers of arousal.

Crisis pathways

Emergency services for acute danger to self or others.

Licensed clinicians diagnose and treat; this atlas does not.

Sources & research

  1. Anxiety disordersCraske MG; et al. · 2017 · Nature Reviews Disease PrimersPrimer on anxiety disorders and mechanisms.DOI
  2. Using Neuroscience to Help Understand Fear and Anxiety: A Two-System FrameworkLeDoux JE; Pine DS · 2016 · American Journal of PsychiatryTwo-system framing of fear vs anxiety circuits.DOI
  3. Epidemiology of anxiety disorders in the 21st centuryBandelow B; Michaelis S · 2015 · Dialogues in Clinical NeuroscienceEpidemiology of anxiety disorders.DOI

Media credits

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