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HOpen questions in hygiene and immunity

Hygiene and balance ? Clean water saves lives; missing old microbial partners is a separate, still-debated immune story.

Researchers still argue which organisms train regulation and whether urban design can supply them safely.

Helminth therapy trials exist in clinics. They are not a backyard project.

Open questions

Which microbes are the Old Friends?

Candidates include certain gut and environmental taxa. A shopping list is not settled.

Can cities design immune-friendly green space?

Biodiversity around homes is studied. Causality is still being unpacked.

Do C-section and formula change set-points?

They change early colonizers. Outcomes vary and are not a verdict on needed surgery.

Is there a safe worm therapy?

Clinical trials test regulated products. Do not import parasites as self-care.

How do we talk without anti-vax capture?

Separate sanitation wins from missing-partner science in every sentence.

The frontier is safer diversity, not nostalgia for cholera.

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