Edward Jenner published cowpox inoculation against smallpox in 1798 after 1796 experiments — the modern vaccine story's usual start. WHO declared smallpox eradicated in 1980 after a global vaccination campaign — the only human infectious disease so far.
IgM often appears first after a new antigen; class-switched IgG later persists and can neutralize or flag pathogens. Memory B and T cells can respond faster on re-exposure — the biological reason boosters and childhood schedules exist.
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Scores are the atlas’s 0–100 teaching marks for each topic. They are not a diagnosis, a dose or a treatment choice.
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All points done. Next: Open the topic: Vaccines and immunity
Edward Jenner published cowpox inoculation against smallpox in 1798 after 1796 experiments — the modern vaccine story's usual start. WHO declared smallpox eradicated in 1980 after a global vaccination campaign — the only human infectious disease so far.
IgM often appears first after a new antigen; class-switched IgG later persists and can neutralize or flag pathogens. Memory B and T cells can respond faster on re-exposure — the biological reason boosters and childhood schedules exist.
Measles is often cited as needing about 92–95% immunity in a community to interrupt chains — a high bar, not a slogan. COVID-19 mRNA vaccines received emergency authorizations in late 2020 after decades of platform research, not overnight invention.
Community effects are arithmetic: if enough people cannot pass a virus on, outbreaks starve. The number depends on the disease. This page is conceptual, not a prescription and not an argument against vaccination. Individual medical choices stay with clinicians.
This is education from the atlas. It does not diagnose and does not prescribe a dose. It does not replace the full topic page.
Next question: Viruses · Open the topic: Vaccines and immunity
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