John Cade
1912–1980 · AustraliaLithium
Introduced lithium into modern psychiatry.
Bipolar Disorder · Mania, depression and the networks between — mood-state biology, sleep disruption and evidence-based stabilising care.
Reviewed 2026-08·Sources & research·Methodology·Media credits
Eight voices who shaped mood-stabiliser science, neuroimaging and clinical guidelines for bipolar disorder.
Portraits resolve via Wikimedia when licences allow.
Lithium
Introduced lithium into modern psychiatry.
Lithium trials
Rigorous evidence for lithium prophylaxis.
Manic-depressive
Classic nosology separating manic-depressive illness.
Lived expertise
Clinician–scholar bridging science and experience.
Neuroimaging
Influential imaging work on bipolar emotion circuitry.
Guidelines
Evidence-based psychopharmacology guidance.
IPSRT
Interpersonal and social rhythm therapy pioneer.
Bipolar science
Major syntheses of manic-depressive illness biology and care.
Read primary papers; this page is not care.
Progressive dementia driven by protein pathology and network failure.
Research 74 🤲Dopamine circuit loss, movement symptoms and non-motor features.
Research 54 ⚡Sudden vascular injury — time, territory and the race to recover.
Research 64 ⚡Hyperexcitable networks, seizures and modern treatment options.
Research 95 🌧️Mood circuits, stress biology and evidence-based interventions.
Research 66 🌀Perception, belief and cognition when predictive models go awry.
Research 93 💢Sensory gain, aura and the brain’s recurrent pain networks.
Research 74 📱Attention control, impulsivity and developmental self-regulation.
Research 51 🧩Neurodevelopmental diversity in social communication and sensory processing.
Research 89 🧬Immune attack on myelin — disconnection across white-matter highways.
Research 80 🩹Mechanical insult, diffuse injury and the long arc of recovery.
Research 87 🔁Compulsive seeking when reward prediction and control circuits tip.
Research 69 😰Threat circuitry, worry loops and avoidance — how brains over-predict danger and how care can recalibrate risk.
Research 86 🛡️Trauma memory, hyperarousal and avoidance — how threat learning overgeneralises and how evidence-based care supports recovery.
Research 87